The evaluation of the leptin implication in postmenopausal osteoporosis

Author: Diana Camelia Bonte 1*, Adrian C. Ilie 1, Radu E. Iacob 2, Rodica Lighezan 1, Ovidiu H. Bonte 3, Daniela Iacob 1 and Andrei Anghel 1
Received 8 October 2012, accepted 22 January 2013.
Abstract

Postmenopausal osteoporosis represents one of the major diseases of modern times and it can be considered an important source of morbidity, mortality and social service spread worldwide. The objectives of this study were the identification of the risk factors involved in postmenopausal osteoporosis, the evaluation of the bone mineral metabolism in postmenopausal women not suffering from osteoporosis and in patients suffering from postmenopausal osteoporosis, as well as the evaluation of the leptin (protein hormone produced by adipocytes) implication in postmenopausal osteoporosis. The study included a control group with 32 postmenopausal women, with bone mass values within normal limits (group 1) and a group of 107 postmenopausal women with osteoporosis (validated by dual energy X-ray absorptiometry DEXA method), without other pathological conditions (group 2). An individual sheet was drawn up for each patient. Each sheet included a general questionnaire (the bone mass index (BMI) was calculated on the basis of the body weight and height), a questionnaire regarding the life style (smoking habits or alcohol consumption), a questionnaire evaluating the daily calcium intake, a questionnaire assessing the physical effort rate, the use of medicines, the evaluation of the estrogenic status). The level of the intact serum parathormone iPTH, 25-hydroxyvitamin D and serum leptin levels were analysed with the ELISA technique. Calcemia and phosphatemia were evaluated with standard methods. We found significant statistical differences between the control group and the group with osteoporosis patients regarding the menopause age (p<0.05), the menarche age (p = 0.006), the number of births (p<0.001) as well as the height and weight (p = 0.03 and p<0.05, respectively). We didn’t find statistically significant differences regarding the serum i-PTH and 25-hydroxyvitamin D. Moreover, we found a statistically significant positive correlation between the BMD and leptin for both groups (group 1 p = 0.01; group 2 p = 0.05). Postmenopausal osteoporosis is a multifactorial disease, the bone loss rate being influenced by several factors (among which the estrogen deficiency plays an important role). Our results suggest that leptin is involved in the regulation of bone mass and bone turnover, having a protective effect against the bone mass loss.

Journal: Food, Agriculture and Environment (JFAE)
Online ISSN: 1459-0263Year: 2013, Vol. 11, Issue 1, pages 244-245. Publisher: WFL.


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