Antihypertensive effect of angiotensin-converting enzyme inhibitory peptides from silver carp (Hypophthalmichthys molitrix) hydrolysate in spontaneously hypertensive rats

Author: Jin-Chao Wu *, Xiao-Lai Shi and Miao Yu
Received 10 October 2012, accepted 24 January 2013.
In order to utilize silver carp (Hypophthalmichthys molitrix), which is abundant and very cheap fresh-water fish in China, defatted silver carp muscle was hydrolysed by compound protease to achieve angiotensin-converting enzyme (ACE) inhibitory peptides. The protein hydrolysates were fractionated into low and high molecular weight fractions using an ultrafiltration (UF) membrane system. The ACE-inhibitory activity tests showed that the low molecular weight fraction was more effective. Most of the peptides in low molecular weight fraction ranged from 600 to 1600 Da. Anti-hypertensive effects of silver carp ACE-inhibitory peptides on spontaneously hypertensive rats (SHR) following oral administration was determined as the tail systolic blood pressure significantly decreased after peptides ingestion.

Journal: Food, Agriculture and Environment (JFAE)
Online ISSN: 1459-0263Year: 2013, Vol. 11, Issue 1, pages 115-117.Publisher: WFL.

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